Accession

PRJCA012927

Title

Proteogenomics landscape of Acute Myeloid Leukemia

Relevance

Medical

Data types

Proteomics

Organisms

Homo sapiens

Description

Acute myeloid leukemia (AML) is a malignant hematological cancer with the worst prognosis of all leukemia categories. Here, we reported a comprehensive proteogenomic analysis of 101 Chinese AML patients, including proteomic, phosphoproteomic analysis and an ex vivo drug sensitivity analysis in addition to Whole exome and transcriptome sequencing. We explored the impact of genomic alterations on proteomic and phosphoproteomic characterizations, and also uncovered the protein and phosphosite panel as prognostic indicators. Proteome-based unsupervised clustering revealed three subtypes with different molecular characterizations and clinical outcomes. Further integrative analysis of drug sensitivity combined with proteomic data showed the novel therapeutic potential of cytarabine-disulfiram combo and PI3Ki-PDKi combo. Our data provided valuable resources for understanding the molecular alterations in AML pathogenesis and clinical therapeutic strategies.

Sample scope

Multiisolate

Release date

2023-02-03

Publication

PubMed ID	Article title	Journal name	DOI	Year
37019911	Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia	Nature Communications	10.1038/s41467-023-37381-4	2023

Grants

Agency	program	Grant ID	Grant title
No funding support

Submitter

Jia Li (jli@simm.ac.cn)

Organization

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Submission date

2022-11-01

Project Data

Resource name	Description
BioSample (157) show	-
SAMC2560534	RNAseq sample_sensitive
SAMC2560530	RNAseq sample_resistant
SAMC2560526	RNAseq sample_resistant
SAMC2560522	RNAseq sample_resistant
SAMC2560519	RNAseq sample_resistant
SAMC2560515	RNAseq sample_sensitive
SAMC2560511	RNAseq sample_resistant
SAMC2560507	RNAseq sample_sensitive
SAMC2560502	RNAseq sample_resistant
SAMC2560499	RNAseq sample_resistant
SAMC2560495	RNAseq sample_sensitive
SAMC2560491	RNAseq sample_sensitive
SAMC2560487	WES sample_sensitive
SAMC2560485	WES sample_resistant
SAMC2560481	WES sample_resistant
SAMC2560477	WES sample_resistant
SAMC2560473	WES sample_resistant
SAMC2560470	WES sample_sensitive
SAMC2560466	WES sample_resistant
SAMC2560462	WES sample_sensitive
SAMC2560459	WES sample_resistant
SAMC2560454	WES sample_resistant
SAMC2560451	WES sample_sensitive
SAMC2560448	WES sample_sensitive
SAMC2540630	RNAseq sample_sensitive
SAMC2540626	RNAseq sample_resistant
SAMC2540622	RNAseq sample_resistant
SAMC2540619	RNAseq sample_resistant
SAMC2540615	RNAseq sample_resistant
SAMC2540611	RNAseq sample_sensitive
SAMC2540607	RNAseq sample_resistant
SAMC2540602	RNAseq sample_sensitive
SAMC2540598	RNAseq sample_resistant
SAMC2540595	RNAseq sample_resistant
SAMC2540592	RNAseq sample_sensitive
SAMC2540588	RNAseq sample_sensitive
SAMC2540586	WES sample_sensitive
SAMC2540583	WES sample_resistant
SAMC2540579	WES sample_resistant
SAMC2540576	WES sample_resistant
SAMC2540572	WES sample_resistant
SAMC2540569	WES sample_sensitive
SAMC2540565	WES sample_resistant
SAMC2540561	WES sample_sensitive
SAMC2540557	WES sample_resistant
SAMC2540553	WES sample_resistant
SAMC2540548	WES sample_sensitive
SAMC2540543	WES sample_sensitive
SAMC2408818	Patient's hair for WES
SAMC2408814	Patient's hair for WES
SAMC2408810	Patient's hair for WES
SAMC2408808	Patient's hair for WES
SAMC2408804	Patient's hair for WES
SAMC2408801	Patient's hair for WES
SAMC2408796	Patient's hair for WES
SAMC2408793	Patient's hair for WES
SAMC2408789	Patient-derived cell lines from AML patient's bone marrow
SAMC2408786	Patient-derived cell lines from AML patient's bone marrow
SAMC2408782	Patient-derived cell lines from AML patient's bone marrow
SAMC2408779	Patient-derived cell lines from AML patient's bone marrow
SAMC2408777	Patient-derived cell lines from AML patient's bone marrow
SAMC2408774	Patient-derived cell lines from AML patient's bone marrow
SAMC2408769	Patient-derived cell lines from AML patient's bone marrow
SAMC2408764	Patient-derived cell lines from AML patient's bone marrow
SAMC2408759	Patient-derived cell lines from AML patient's bone marrow
SAMC2408754	Patient-derived cell lines from AML patient's bone marrow
SAMC2408750	Patient-derived cell lines from AML patient's bone marrow
SAMC2408744	Patient-derived cell lines from AML patient's bone marrow
SAMC2408740	Patient-derived cell lines from AML patient's bone marrow
SAMC2408734	Patient-derived cell lines from AML patient's bone marrow
SAMC2408731	Patient-derived cell lines from AML patient's bone marrow
SAMC2408725	Patient-derived cell lines from AML patient's bone marrow
SAMC2408718	Patient-derived cell lines from AML patient's bone marrow
SAMC2408714	Patient-derived cell lines from AML patient's bone marrow
SAMC2408708	Patient-derived cell lines from AML patient's bone marrow
SAMC2408704	Patient-derived cell lines from AML patient's bone marrow
SAMC2408699	Patient-derived cell lines from AML patient's bone marrow
SAMC2408693	Patient-derived cell lines from AML patient's bone marrow
SAMC2408689	Patient-derived cell lines from AML patient's bone marrow
SAMC2408685	Patient-derived cell lines from AML patient's bone marrow
SAMC2408680	Patient-derived cell lines from AML patient's bone marrow
SAMC2408673	Patient-derived cell lines from AML patient's bone marrow
SAMC2408668	Patient-derived cell lines from AML patient's bone marrow
SAMC2408663	Patient-derived cell lines from AML patient's bone marrow
SAMC2408660	Patient-derived cell lines from AML patient's bone marrow
SAMC2408656	Patient-derived cell lines from AML patient's bone marrow
SAMC2408652	Patient-derived cell lines from AML patient's bone marrow
SAMC2408648	Patient-derived cell lines from AML patient's bone marrow
SAMC2408645	Patient-derived cell lines from AML patient's bone marrow
SAMC2408640	Patient-derived cell lines from AML patient's bone marrow
SAMC2408635	Patient-derived cell lines from AML patient's bone marrow
SAMC2408632	Patient-derived cell lines from AML patient's bone marrow
SAMC2408628	Patient-derived cell lines from AML patient's bone marrow
SAMC2408624	Patient-derived cell lines from AML patient's bone marrow
SAMC2408620	Patient-derived cell lines from AML patient's bone marrow
SAMC2408615	Patient-derived cell lines from AML patient's bone marrow
SAMC2408612	Patient-derived cell lines from AML patient's bone marrow
SAMC2408609	Patient-derived cell lines from AML patient's bone marrow
SAMC2408605	Patient-derived cell lines from AML patient's bone marrow
SAMC2408602	Patient-derived cell lines from AML patient's bone marrow
SAMC2408598	Patient-derived cell lines from AML patient's bone marrow
SAMC2408594	Patient-derived cell lines from AML patient's bone marrow
SAMC2408592	Patient-derived cell lines from AML patient's bone marrow
SAMC2408586	Patient-derived cell lines from AML patient's bone marrow
SAMC2408582	Patient-derived cell lines from AML patient's bone marrow
SAMC2408578	Patient-derived cell lines from AML patient's bone marrow
SAMC2408575	Patient-derived cell lines from AML patient's bone marrow
SAMC2408570	Patient-derived cell lines from AML patient's bone marrow
SAMC2408566	Patient-derived cell lines from AML patient's bone marrow
SAMC2408562	Patient-derived cell lines from AML patient's bone marrow
SAMC2408557	Patient-derived cell lines from AML patient's bone marrow
SAMC2408553	Patient-derived cell lines from AML patient's bone marrow
SAMC2408550	Patient-derived cell lines from AML patient's bone marrow
SAMC2408545	Patient-derived cell lines from AML patient's bone marrow
SAMC2408539	Patient-derived cell lines from AML patient's bone marrow
SAMC2408535	Patient-derived cell lines from AML patient's bone marrow
SAMC2408531	Patient-derived cell lines from AML patient's bone marrow
SAMC2408527	Patient-derived cell lines from AML patient's bone marrow
SAMC2408522	Patient-derived cell lines from AML patient's bone marrow
SAMC2408517	Patient-derived cell lines from AML patient's bone marrow
SAMC2408513	Patient-derived cell lines from AML patient's bone marrow
SAMC2408508	Patient-derived cell lines from AML patient's bone marrow
SAMC2408504	Patient-derived cell lines from AML patient's bone marrow
SAMC2408501	Patient-derived cell lines from AML patient's bone marrow
SAMC2408497	Patient-derived cell lines from AML patient's bone marrow
SAMC2408493	Patient-derived cell lines from AML patient's bone marrow
SAMC2408490	Patient-derived cell lines from AML patient's bone marrow
SAMC2408486	Patient-derived cell lines from AML patient's bone marrow
SAMC2408482	Patient-derived cell lines from AML patient's bone marrow
SAMC2408479	Patient-derived cell lines from AML patient's bone marrow
SAMC2408476	Patient-derived cell lines from AML patient's bone marrow
SAMC2408473	Patient-derived cell lines from AML patient's bone marrow
SAMC2408469	Patient-derived cell lines from AML patient's bone marrow
SAMC2408465	Patient-derived cell lines from AML patient's bone marrow
SAMC2408462	Patient-derived cell lines from AML patient's bone marrow
SAMC2408457	Patient-derived cell lines from AML patient's bone marrow
SAMC2408454	Patient-derived cell lines from AML patient's bone marrow
SAMC2408451	Patient-derived cell lines from AML patient's bone marrow
SAMC2408447	Patient-derived cell lines from AML patient's bone marrow
SAMC2408443	Patient-derived cell lines from AML patient's bone marrow
SAMC2408439	Patient-derived cell lines from AML patient's bone marrow
SAMC2408435	Patient-derived cell lines from AML patient's bone marrow
SAMC2408430	Patient-derived cell lines from AML patient's bone marrow
SAMC2408426	Patient-derived cell lines from AML patient's bone marrow
SAMC2408423	Patient-derived cell lines from AML patient's bone marrow
SAMC2408416	Patient-derived cell lines from AML patient's bone marrow
SAMC2408412	Patient-derived cell lines from AML patient's bone marrow
SAMC2408408	Patient-derived cell lines from AML patient's bone marrow
SAMC2408403	Patient-derived cell lines from AML patient's bone marrow
SAMC2408399	Patient-derived cell lines from AML patient's bone marrow
SAMC2408395	Patient-derived cell lines from AML patient's bone marrow
SAMC2408391	Patient-derived cell lines from AML patient's bone marrow
SAMC2408387	Patient-derived cell lines from AML patient's bone marrow
SAMC2408383	Patient-derived cell lines from AML patient's bone marrow
SAMC2408380	Patient-derived cell lines from AML patient's bone marrow
SAMC2408375	Patient-derived cell lines from AML patient's bone marrow
SAMC2408373	Patient-derived cell lines from AML patient's bone marrow