| Accession |
PRJCA013130 |
| Title |
Precise classification of immune cells in colorectal cancer and related functional mechanisms |
| Relevance |
Medical |
| Data types |
Genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
This study aims to accurately classify the immune cells in colorectal cancer (CRC), adjacent tissues and peripheral blood, and to investigate the functions and potential molecular mechanisms of different immune cell subsets in the occurrence and development of CRC at the single-cell transcriptome level. At the same time, metabolomics, metagenomics and animal models are used to explore the effects of specific mutations or metabolic molecules on the immune response and function of immune cells. |
| Sample scope |
Multiisolate |
| Release date |
2023-02-08 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36990096
|
An immunometabolism subtyping system identifies S100A9+ macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis
|
Cell Reports
|
10.1016/j.xcrm.2023.100987
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81472210
|
|
|
|
| Submitter |
Weijia
Fang (weijiafang@zju.edu.cn)
|
| Organization |
Zhejiang University |
| Submission date |
2022-11-10 |
