| Accession |
PRJCA013167 |
| Title |
Immune repertoire profiling reveals its clinical application potential and triggers for Neuromyelitis Optica Spectrum Disorders |
| Relevance |
Medical |
| Data types |
TCR repertoire sequencing
|
| Organisms |
Homo sapiens
|
| Description |
In this study, we performed high throughput T cell receptor (TCR) sequencing on 151 patients with neuromyelitis optica spectrum disorders (NMOSD) and 151 healthy individuals from the West China Hospital of Sichuan University. All patients with NMOSD were seropositive for anti-AQP4 antibodies. In addition, we treated 28 AQP4-IgG+ NMOSD patients with immunosuppressants and followed them for 6 months to compare changes in NMOSD-specific TCRs (NMOSD-TCRs) before and after treatment. |
| Sample scope |
Multiisolate |
| Release date |
2023-09-13 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37414573
|
Immune Repertoire Profiling Reveals Its Clinical Application Potential and Triggers for Neuromyelitis Optica Spectrum Disorders
|
Neurol Neuroimmunol Neuroinflamm
|
10.1212/NXI.0000000000200134
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| West China Hospital of Sichuan University
|
|
141141112
|
SCI Foundation of West China Hospital of Sichuan University
|
|
|
| Submitter |
Hong-yu
Zhou (zhouhy@scu.edu.cn)
|
| Organization |
West China Hospital of Sichuan University |
| Submission date |
2022-11-12 |
