| Accession |
PRJCA013213 |
| Title |
CircRNA microarray expression profiling of peripheral blood mononuclear cell in FT1D patients |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Circular RNAs (circRNAs), a new class of non-coding RNAs, are characterized by a closed-loop structure, resistance to degradation, and excellent stability. Numbers of studies have shown that circRNAs are involved in many physiological and pathological disease processes, and can serve as diagnostic and prognostic molecular biomarkers. Our previous study showed that circRNAs are aberrantly expressed in the peripheral blood of patients with T1D and may contribute to T1D disease progression through interactions with miRNA and circRNA-derived peptides. Other studies have shown that circRNAs can promote onset and progression of T1D. However, the expression profiles of circRNAs and the value of circRNAs as biomarkers of FT1D have not been characterized. We investigated the circRNA expression profiles in peripheral blood mononuclear cells (PBMCs) from patients with FT1D using microarray data, analyzed their biological functions using bioinformatics, and validated their expression levels using quantitative real-time PCR (qRT-PCR). |
| Sample scope |
Multiisolate |
| Release date |
2023-03-13 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Identification of hsa_circRNA_100632 as a novel molecular biomarker for fulminant type 1 diabetes
|
Frontiers in Immunology
|
10.3389/fimmu.2023.1075970
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Hunan Province Natural Science Funds for Distinguished Young Scholar
|
|
2020JJ2053
|
|
| key projects supported by the Hunan Health Commission
|
|
202103060904
|
|
|
|
| Submitter |
Shuoming
Luo (shuomingluo@csu.edu.cn)
|
| Organization |
The Second Xiangya Hospital of Central South University |
| Submission date |
2022-11-14 |
