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Accession PRJCA013448
Title Integrative Proteomic Characterization of Adenocarcinoma of Esophagogastric Junction
Relevance Medical
Data types Exome
Transcriptome or Gene expression
Multi omics data
Organisms Homo sapiens
human
Description The incidence of adenocarcinoma of the esophagogastric junction (AEG), which is a different cancer type from gastric and esophageal cancers, has been rapidly increasing in recent decades. However, the molecular alterations and subtypes of AEG are still obscure. Here, we aimed to portray the molecular landscape and identify the molecular subtypes of AEG. We conducted proteomics and phosphoproteomics profiling of 103 AEG tumors with paired normal adjacent tissues (NATs), whole exome sequencing (WES) of 94 tumor-NAT pairs, and RNA sequencing (RNA-seq) in 83 tumor-NAT pairs. Our proteogenomics dataset provides a valuable resource for better understanding the molecular mechanisms of AEG and the development of precision treatment strategies for AEG patients.
Sample scope Multiisolate
Release date 2022-11-24
Grants
Agency program Grant ID Grant title
National Key Research and Development Program of China Key Program 2021YFA0910100
Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer JBZX-202006
Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2202
Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2104
National Natural Science Foundation of China 82074245
National Natural Science Foundation of China 81973634
National Natural Science Foundation of China 81903842
Natural Science Foundation of Zhejiang Province LR21H280001
Science and Technology Projects of Zhejiang Province 2019C03049
Program of Zhejiang Provincial TCM Sci-tech Plan 2018ZY006
Program of Zhejiang Provincial TCM Sci-tech Plan 2020ZZ005
Submitter Xiangdong Cheng (chengxd@zjcc.org.cn)
Organization Zhejiang Cancer Hospital
Submission date 2022-11-24

Project Data

Resource name Description
BioSample (202)  show -