| 项目编号 | PRJCA013456 | ||||||||||||||||||||||||
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| 项目标题 | Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV to mammals | ||||||||||||||||||||||||
| 涉及领域 | Model organism | ||||||||||||||||||||||||
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads |
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| 物种名称 |
Atelerix albiventris
Callosciurus erythraeus Chaerephon plicatus Nyctereutes procyonoides Tylonycteris robustula Eonycteris spelaea Petaurus breviceps Pteropus alecto Oryctolagus cuniculus Murina leucogaster Pipistrellus javanicus Myotis siligorensis Paguma larvata Cavia porcellus Myotis ricketti Aselliscus stoliczkanus Rhinolophus malayanus Monodelphis domestica Mustela putorius Vulpes vulpes Hipposideros pomona Procavia capensis Myotis fimbriatus Rhinolophus ferrumequinum Bos taurus Myotis laniger Plecotus auritus Neogale vison Rhinolophus rex Graphiurus kelleni Pipistrellus abramus Myotis muricola Myotis chinensis Heterocephalus glaber Miniopterus fuliginosus |
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| 描述信息 | Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first performed on 83 cell cultures derived from 55 mammalian species using pseudotyped viruses bearing S proteins from SARS-CoV-2, SARS-CoV, and MERS-CoV. Cell cultures from Thomas's horseshoe bat, king horseshoe bat, green monkey, and ferret were found to be highly susceptible to SARS-CoV-2, SARS-CoV, and MERS-CoV pseudotyped viruses. Moreover, five variants (del69-70, D80Y, S98F, T572I, and Q675H) that beside spike receptor-binding domain can significantly alter the host tropism of SARS-CoV-2. An examination of phylogenetic signals of transduction rates revealed that closely related taxa generally have similar susceptibility to MERS-CoV but not to SARS-CoV and SARS-CoV-2 pseudotyped viruses. Additionally, we discovered the expression of entry receptors, i.e., ACE2 and DPP4, shown poor correlation with susceptibility to infection across mammalian taxa. This study provides a basic documentation of likely susceptibility, variants, and molecules that underline the cross-species transmission of these coronaviruses. | ||||||||||||||||||||||||
| 样品范围 | Multispecies | ||||||||||||||||||||||||
| 发布日期 | 2023-06-12 | ||||||||||||||||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Xuming Zhou (zhouxuming@ioz.ac.cn) | ||||||||||||||||||||||||
| 提交单位 | Institute of Zoology, Chinese Academy of Sciences | ||||||||||||||||||||||||
| 提交日期 | 2022-11-24 |