| 项目编号 |
PRJCA013670 |
| 项目标题 |
Cancer induces cachexia via promoting adipose tissue metabolic remodeling |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Metabonomics and phosphoproteomics
|
| 物种名称 |
Mus musculus
Homo sapiens
|
| 描述信息 |
Cancer cachexia is a multifactorial syndrome featured by a rapid reduction of body weight and accounts for 20-40% of cancer-related death. However, its underlying mechanism is poorly understood. We performed untargeted metabolomics analysis of serum samples from mouse and patients with lung cancer induced cachexia to investigate the cachexia related metabolic change. The wasting of adipose tissue has an important role in the occurrence of cachexia. We performed RNA-sequencing and phosphoproteomics analysis of inguinal white adipose tissue from health and cachectic mice. In the cachexia group, 1*106 LLC cells were subcutaneously injected to the right flank of mice. Tissue samples were collected 24 days after cancer cells injection. This work revealed the mechanism underlying the development of cachexia. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-03-18 |
| 出版信息 |
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0800701
|
|
|
|
| 提交者 |
Xinli
Hu (huxxx025@pku.edu.cn)
|
| 提交单位 |
Peking University |
| 提交日期 |
2022-12-05 |
