| Accession |
PRJCA013670 |
| Title |
Cancer induces cachexia via promoting adipose tissue metabolic remodeling |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Metabonomics and phosphoproteomics
|
| Organisms |
Mus musculus
Homo sapiens
|
| Description |
Cancer cachexia is a multifactorial syndrome featured by a rapid reduction of body weight and accounts for 20-40% of cancer-related death. However, its underlying mechanism is poorly understood. We performed untargeted metabolomics analysis of serum samples from mouse and patients with lung cancer induced cachexia to investigate the cachexia related metabolic change. The wasting of adipose tissue has an important role in the occurrence of cachexia. We performed RNA-sequencing and phosphoproteomics analysis of inguinal white adipose tissue from health and cachectic mice. In the cachexia group, 1*106 LLC cells were subcutaneously injected to the right flank of mice. Tissue samples were collected 24 days after cancer cells injection. This work revealed the mechanism underlying the development of cachexia. |
| Sample scope |
Multiisolate |
| Release date |
2024-03-18 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0800701
|
|
|
|
| Submitter |
Xinli
Hu (huxxx025@pku.edu.cn)
|
| Organization |
Peking University |
| Submission date |
2022-12-05 |
