| 描述信息 |
Understanding human genomic variation could help yield insights into the population history and genetic basis of phenotypic diversity and disease etiology. Guizhou province (GZ), located southwest of China, have 18 resident ethnic groups and the ethnic minorities account for 37% of the province, represents an abundant resource for the study of the genetic. However, there are currently very few large-scale genome cohorts and no in-depth whole-genome sequencing (WGS) study on Guizhou local populations. We initiated the population genetic study with deep sequencing GZ individuals. Method: The whole blood was collected from three ethnics in Guizhou provinces in China, including 156 Bouyei, 160 Dong, and 147 Miao. DNA was extracted and sequenced on DNBSEQ T1 platform with 100bp paired-end reads. 26 samples were excluded because of low sequencing depth, duplicated individuals or MZ twins. The whole-genome sequencing analysis pipelines was built including variant calling and identification, population structure analysis. |
