| Accession |
PRJCA013709 |
| Title |
Plasma Landscape of Proteins and Metabolites in Acute Promyelocytic Leukemia |
| Relevance |
Medical |
| Data types |
Proteomics and Metabolomics
|
| Organisms |
Homo sapiens
|
| Description |
The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Here we reported a cross-sectional correlation network framework that was successfully applied to interpret multi-layered datasets on clinical laboratory tests, proteomes, and metabolomes of paired plasma samples from APL patients before or after ATRA/ATO remission induction therapy. Our study identified an untreated APL plasma network, revealing two prominent features: one characterized by altered secretory protein and metabolite profiles, indicative of heightened proliferative and energy consumption states of APL blasts; the other featuring APL plasma-enriched proteins, or enzymes catalyzing the metabolism of plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA, suggesting a possible involvement of APL blasts in modulating their plasma microenvironment. This work sheds new light into the pathophysiology and treatment of APL and provides an information-rich reference data cohort for exploratory and translational study of leukemia microenvironment. |
| Sample scope |
Multiisolate |
| Release date |
2023-08-13 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Niu
Qiao (mika_qiao@sjtu.edu.cn)
|
| Organization |
Shanghai Jiao Tong University |
| Submission date |
2022-12-06 |
