| Accession |
PRJCA013766 |
| Title |
GLI1 inhibitor (GANT61) suppressed chondrosarcoma growth |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
Homo sapiens/Mus musculus xenograft
|
| Description |
To validate the anti-tumor effects of GANT-61 were reflected at gene expression levels, we performed microarray-based transcriptomic profiling of chondrosarcoma subcutaneous tumor tissues.8 mices were randomly divided equally into two groups. 100μL GANT61 (60 mg/kg) or ethanol (negative control) were injected intravenous every 3 days a total of 6 times beginning at day 5 after tumor inoculation. |
| Sample scope |
Monoisolate |
| Release date |
2022-12-09 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37488121
|
ANT-61 induces cell cycle resting and autophagy by down-regulating RNAP III signal pathway and tRNA-Gly-CCC synthesis to combate chondrosarcoma
|
Cell Death & Disease
|
10.1038/s41419-023-05926-6
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
81702667
|
|
|
|
| Submitter |
Yifeng
Sun (498054232@qq.com)
|
| Organization |
The First Affiliated Hospital of Shandong First Medical University &Shandong Provincial Qianfoshan Hospital |
| Submission date |
2022-12-09 |
