Accession

PRJCA013812

Title

Discovered biomarkers for predicting esophageal squamous precancerous lesions to cancer transition

Relevance

Medical

Data types

Raw sequence reads

Organisms

Homo sapiens

Description

Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal squamous cell carcinoma (ESCC) including low-grade (LGIN) and high-grade (HGIN) intraepithelial neoplasia. Because of lack molecular biomarkers, which ESPL will eventually develop to ESCC and thus should be treated is not well defined. We performed spatial whole-transcriptome atlas (WTA) analysis to discover biomarkers for predicting risks of ESCC when people are diagnosed with ESPL even at LGIN stage.

Sample scope

Multiisolate

Release date

2023-07-06

Publication

PubMed ID	Article title	Journal name	DOI	Year
37553345	Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer	Nature Communications	10.1038/s41467-023-40343-5	2023

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		81802875
National Natural Science Foundation of China (NSFC)		81802876
National Natural Science Foundation of China (NSFC)		82073075
National Natural Science Foundation of China (NSFC)		82172996
Training plan for young backbone teachers of Henan Province		2020GGJS010
Basic research and Cultivation Fund for young teachers of Zhengzhou University		JC202035023
Science and technology innovation talents support plan of Henan Province		21HASTIT048
The Science and Technology Project of Henan Province		212102310880
The Science and Technology Project of Henan Province		22102310416
The Key projects jointly built by Henan Province and the Ministry of Finance		SBGJ202102071

Submitter

Xiang Li (xli@hci-cn.org)

Organization

China-US (Henan) Hormel Cancer Institute

Submission date

2022-12-10

Project Data

Resource name	Description