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Accession PRJCA013812
Title Discovered biomarkers for predicting esophageal squamous precancerous lesions to cancer transition
Relevance Medical
Data types Raw sequence reads
Organisms Homo sapiens
Description Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal squamous cell carcinoma (ESCC) including low-grade (LGIN) and high-grade (HGIN) intraepithelial neoplasia. Because of lack molecular biomarkers, which ESPL will eventually develop to ESCC and thus should be treated is not well defined. We performed spatial whole-transcriptome atlas (WTA) analysis to discover biomarkers for predicting risks of ESCC when people are diagnosed with ESPL even at LGIN stage.
Sample scope Multiisolate
Release date 2023-07-06
Publication
PubMed ID Article title Journal name DOI Year
37553345 Spatial transcriptomics analysis of esophageal squamous precancerous lesions and their progression to esophageal cancer Nature Communications 10.1038/s41467-023-40343-5 2023
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 81802875
National Natural Science Foundation of China (NSFC) 81802876
National Natural Science Foundation of China (NSFC) 82073075
National Natural Science Foundation of China (NSFC) 82172996
Training plan for young backbone teachers of Henan Province 2020GGJS010
Basic research and Cultivation Fund for young teachers of Zhengzhou University JC202035023
Science and technology innovation talents support plan of Henan Province 21HASTIT048
The Science and Technology Project of Henan Province 212102310880
The Science and Technology Project of Henan Province 22102310416
The Key projects jointly built by Henan Province and the Ministry of Finance SBGJ202102071
Submitter Xiang Li (xli@hci-cn.org)
Organization China-US (Henan) Hormel Cancer Institute
Submission date 2022-12-10

Project Data

Resource name Description
BioSample (43)  show -