| Accession |
PRJCA013905 |
| Title |
Dynamic analysis of pathogenesis and a suppression function of TREM2-dependent macrophages in skin fibrosis |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, and fibrosis is the distinguishing hallmark in the pathogenesis. Identification of the precise, time-dependent composition of stromal and immune cells may provide clues for the establishment of new biomarkers and therapeutic approaches targeting SSc fibrosis. Here, the temporal dynamics of pathological process in a mouse model of skin fibrosis is investigated using single-cell RNA-sequencing (scRNA-seq). |
| Sample scope |
Single cell |
| Release date |
2023-12-01 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81471553
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81872530
|
|
|
|
| Submitter |
Yongfei
Hu (yongfei_hu_joe@163.com)
|
| Organization |
Southern Medical University |
| Submission date |
2022-12-15 |
