| 项目编号 |
PRJCA013905 |
| 项目标题 |
Dynamic analysis of pathogenesis and a suppression function of TREM2-dependent macrophages in skin fibrosis |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, and fibrosis is the distinguishing hallmark in the pathogenesis. Identification of the precise, time-dependent composition of stromal and immune cells may provide clues for the establishment of new biomarkers and therapeutic approaches targeting SSc fibrosis. Here, the temporal dynamics of pathological process in a mouse model of skin fibrosis is investigated using single-cell RNA-sequencing (scRNA-seq). |
| 样品范围 |
Single cell |
| 发布日期 |
2023-12-01 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38505612
|
Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages
|
Theranostics
|
10.7150/thno.94121
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81471553
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81872530
|
|
|
|
| 提交者 |
Yongfei
Hu (yongfei_hu_joe@163.com)
|
| 提交单位 |
Southern Medical University |
| 提交日期 |
2022-12-15 |
