| 描述信息 |
Epithelial ovarian cancer (EOC) is one of the most common gynecologic malignancies of the female reproductive system worldwide, characterized by high metastasis, chemotherapy resistance and recurrence after surgery. To characterize the molecular phenotypic features and potential oncogenic mechanisms of EOC, we performed a comprehensive mass spectrometry-based proteomic profiling of the EOC cohort. Comparing the proteomes of EOC and normal adjacent tissues, we revealed a catalog of dysregulated proteins. Next, we identified dysregulated proteins and phosphorylation sites with significant level differences in some important pathways by integrating our cohort with the CPTAC cohort, evaluated the diagnostic and prognostic value of these proteins. Moreover, protein co-expression network was constructed, which not only provided a comprehensive view of the biological features of each histological subtype, but also to nominated potential prognostic biomarkers and progression landmarks. Notably, EOC had strong inter-tumor heterogeneity, with significantly different staging, grading, differentiation, survival, and recurrence rates in serous carcinoma, endometrioid carcinoma and clear cell carcinoma. The proteomic patterns corresponding to the different subtypes were specified, these subtypes have different abnormal pathways. Specifically, compared with other subtypes, cell signaling pathways and intracellular transport pathways were significantly enriched in the serous subtype, indicating the associations with poor clinical outcomes. Finally, we predicted potential therapeutic agents and drug targets for each histological subtype separately, based on protein expression levels, prognostic ability and druggability. Taken together, our proteomic analysis characterizes histological subtypes of EOC, thus providing a potential therapeutic outlook for improving disease outcomes in patients with EOC. |
