| Accession |
PRJCA014366 |
| Title |
Lhx2 induces global changes of RGC transcriptome |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
Axons of retinal ganglion cells (RGCs) converge to form the optic nerve. The damage or loss of RGCs and their axons accounting for the visual functional defects are observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as optic glioma. Unfortunately, there are no effective clinical treatments for these neurodegenerative diseases and nerve damage, one of the main reasons is the loss of the ability of mature neurons in the mammalian central nervous system to regenerate. Here, we report that LIM homeodomain transcription factor Lhx2 promotes axon regeneration and RGC survival after optic nerve or excitotoxicity injury. Further, mechanism exploration by RNA-seq, we reveal that Lhx2 supports axon regeneration by systematically silencing the transcription of genes regulating axon guidance and regenerative-related signaling. Especially, we confirm that Lhx2 induces axon regeneration of RGCs by inhibiting Semaphorin 3C transcription. |
| Sample scope |
Multiisolate |
| Release date |
2025-01-11 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82271428/31900690/82130029
|
|
| Chinese Academy of Sciences (CAS)
|
|
CAS-WX2021SF-0301
|
|
| National Key Research and Development Program of China Project
|
|
2021YFA1101402/2018YFA0108001
|
|
| Strategic Priority Research Program of the Chinese Academy of Sciences
|
|
XDA16010300/XDA16021400
|
|
|
|
| Submitter |
LIU
CHANGMEI (liuchm@ioz.ac.cn)
|
| Organization |
Institute of Zoology, Chinese Academy of Sciences |
| Submission date |
2023-01-11 |
