| 项目编号 |
PRJCA014366 |
| 项目标题 |
Lhx2 induces global changes of RGC transcriptome |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Axons of retinal ganglion cells (RGCs) converge to form the optic nerve. The damage or loss of RGCs and their axons accounting for the visual functional defects are observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as optic glioma. Unfortunately, there are no effective clinical treatments for these neurodegenerative diseases and nerve damage, one of the main reasons is the loss of the ability of mature neurons in the mammalian central nervous system to regenerate. Here, we report that LIM homeodomain transcription factor Lhx2 promotes axon regeneration and RGC survival after optic nerve or excitotoxicity injury. Further, mechanism exploration by RNA-seq, we reveal that Lhx2 supports axon regeneration by systematically silencing the transcription of genes regulating axon guidance and regenerative-related signaling. Especially, we confirm that Lhx2 induces axon regeneration of RGCs by inhibiting Semaphorin 3C transcription. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-01-11 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82271428/31900690/82130029
|
|
| Chinese Academy of Sciences (CAS)
|
|
CAS-WX2021SF-0301
|
|
| National Key Research and Development Program of China Project
|
|
2021YFA1101402/2018YFA0108001
|
|
| Strategic Priority Research Program of the Chinese Academy of Sciences
|
|
XDA16010300/XDA16021400
|
|
|
|
| 提交者 |
LIU
CHANGMEI (liuchm@ioz.ac.cn)
|
| 提交单位 |
Institute of Zoology, Chinese Academy of Sciences |
| 提交日期 |
2023-01-11 |
