| 项目编号 |
PRJCA014374 |
| 项目标题 |
Hemicellulose alleviated intestinal mucosal barrier impairment and modulated gut microbiota and metabolome in T2DM mice |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
|
| 物种名称 |
mouse gut metagenome
Mus musculus
|
| 描述信息 |
Whether supplementation of hemicellulose could reduce hyperglycemia and repair the gut barrier and its underlying mechanism in type 2 diabetes mellitus (T2DM) remains unclear. Mice were categorized into 4 different groups: db/db mice fed by compositionally defined diet (CDD), db/db mice fed by CDD with 10% and 20% hemicellulose supplementation, and control mice fed by CDD. Body weight and fasting blood glucose levels were monitored weekly. The gut barrier was evaluated. Fresh stool samples were analyzed by metagenomic sequencing and liquid chromatography-mass spectrometry to detect the changes of the gut microbiota and metabolome. Systemic and colonic inflammation were evaluated |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-01-13 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36825092
|
Effects of hemicellulose on intestinal mucosal barrier integrity, gut microbiota, and metabolomics in a mouse model of type 2 diabetes mellitus
|
Frontiers in Microbiology
|
10.3389/fmicb.2023.1096471
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81970464
|
|
|
|
| 提交者 |
Huan
Liu (liuh85@mail3.sysu.edu.cn)
|
| 提交单位 |
Sun Yat-sen University |
| 提交日期 |
2023-01-11 |
