| Accession |
PRJCA014451 |
| Title |
Single-cell sequencing dissecting the metabolic and cell fate heterogeneity of proliferative stem cells during stomach regeneration |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Mus musculus
|
| Description |
Spasmolytic peptide expressing metaplasia arises from mature gastric chief cells dedifferentiating and re-entering the cell cycle following an evolutionarily conserved process termed paligenosis. We characterized single-cell transcriptomes of 11 samples following injury to the murine stomach to analyze mechanisms promoting paligenosis. Our high-resolution study increases our understanding of how metabolic and mitochondrial changes are necessary for stomach regeneration. |
| Sample scope |
Single cell |
| Release date |
2024-02-29 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38521055
|
Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
|
Developmental Cell
|
10.1016/j.devcel.2024.03.002
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Key Research and Development Program of China
|
|
2022YFA1105300
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82072724
|
|
| Department of Education of Liaoning Province
|
|
QNZR2020004
|
|
| Department of Education of Liaoning Province
|
|
2021-YQ-07
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81961128026
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U1908207
|
|
| Overseas training project of Liaoning general higher education
|
|
2019GJWYB022
|
|
| China Postdoctoral Science Foundation
|
|
2022TQ0373
|
|
|
|
| Submitter |
Zhenning
Wang (josieon826@sina.cn)
|
| Organization |
The First Hospital of China Medical University |
| Submission date |
2023-01-14 |
