| Accession |
PRJCA014521 |
| Title |
Effect of poly (I:C) combined with radiotherapy on the transcriptome of hepatocellular carcinoma cells |
| Relevance |
Model organism |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
Hepa1-6 cells were subcutaneously injected into the right hind limbs (defined as Tumor1) and left forelimb armpit (defined as Tumor2) of C57BL/6 mice respectively. Seven days after the inoculation, the tumors were established. For evaluating the efficacy of combing poly(I:C) with RT, the bilateral HCC subcutaneous tumor bearing mice were randomly divided into four groups, including normal saline (NS) treated group, poly(I:C) treated group, RT treated group, and poly(I:C) plus RT treated group. The mice were administered with poly(I:C) (200 µg per mouse) or NS (200 µl per mouse) by subcutaneous injection at the day1, day3 and day5~day11 of treatment procedure. In the experimental group that received RT, the tumor1 in tumor-bearing mice was irradiated with a total dose of 40 Gy (8Gy*5days). Total RNA of C57BL/6 mouse tumor tissues (3 tissues/group) was extracted. RNA library sequencing was performed by Berry Genomics on illumina Novoseq 6000 (paired end, 150bp). |
| Sample scope |
Multiisolate |
| Release date |
2023-09-15 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis
|
EMBO Molecular Medicine
|
10.1038/s44321-024-00068-4
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
U22A20328
|
Spleen-targeted neoantigen vaccine for precise immunotherapy of liver cancer
|
|
|
| Submitter |
Xiaolong
Liu (xiaoloong.liu@gmail.com)
|
| Organization |
Mengchao Hepatobiliary Hospital of Fujian Medical University |
| Submission date |
2023-01-19 |
