| 项目编号 |
PRJCA014521 |
| 项目标题 |
Effect of poly (I:C) combined with radiotherapy on the transcriptome of hepatocellular carcinoma cells |
| 涉及领域 |
Model organism |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
Mus
|
| 描述信息 |
Hepa1-6 cells were subcutaneously injected into the right hind limbs (defined as Tumor1) and left forelimb armpit (defined as Tumor2) of C57BL/6 mice respectively. Seven days after the inoculation, the tumors were established. For evaluating the efficacy of combing poly(I:C) with RT, the bilateral HCC subcutaneous tumor bearing mice were randomly divided into four groups, including normal saline (NS) treated group, poly(I:C) treated group, RT treated group, and poly(I:C) plus RT treated group. The mice were administered with poly(I:C) (200 µg per mouse) or NS (200 µl per mouse) by subcutaneous injection at the day1, day3 and day5~day11 of treatment procedure. In the experimental group that received RT, the tumor1 in tumor-bearing mice was irradiated with a total dose of 40 Gy (8Gy*5days). Total RNA of C57BL/6 mouse tumor tissues (3 tissues/group) was extracted. RNA library sequencing was performed by Berry Genomics on illumina Novoseq 6000 (paired end, 150bp). |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-09-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis
|
EMBO Molecular Medicine
|
10.1038/s44321-024-00068-4
|
2024
|
| 38671318
|
TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis
|
EMBO Molecular Medicine
|
10.1038/s44321-024-00068-4
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
U22A20328
|
Spleen-targeted neoantigen vaccine for precise immunotherapy of liver cancer
|
|
|
| 提交者 |
Xiaolong
Liu (xiaoloong.liu@gmail.com)
|
| 提交单位 |
Mengchao Hepatobiliary Hospital of Fujian Medical University |
| 提交日期 |
2023-01-19 |
