| 项目编号 |
PRJCA014589 |
| 项目标题 |
Study on diagnosis, treatment and pathogenesis of ROSAH disease |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
ROSAH syndrome is a class of clinical symptoms characterized by retinal dysplasia, optic nerve edema, splenomegaly, anhidrosis and migraine. It is a newly recognized inflammatory disease. We have developed a highly effective inhibitor of ALPK1, and planned to use peripheral blood mononuclear cells of patients for preliminary in vitro efficacy study. The inhibitory effect of ALPK1 inhibitor on inflammation was observed, and the pathogenesis of ROASH was further studied by transcriptome and proteome analysis. The peripheral blood cells were differentiated into IPSC cells to study the mechanism and pharmacodynamics |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-01-28 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Shanghai Yaoyuan Biotechnology Co., LTD
|
|
2021SQCJ2890
|
|
|
|
| 提交者 |
Hongmei
Song (Songhm1021@126.com)
|
| 提交单位 |
Peking Union Hospital, Chinese Academy of Medical Sciences |
| 提交日期 |
2023-01-28 |
