| Accession |
PRJCA014655 |
| Title |
A large-scale genome-wide association and meta-analysis of 7284 leprosy patients and 7738 healthy controls |
| Relevance |
Medical |
| Data types |
Phenotype or Genotype
Variation
|
| Organisms |
Homo sapiens
|
| Description |
To date, genome-wide association studies (GWASs) have discovered 35 susceptible loci of leprosy; however, the cumulative effects of these loci can only partially explain the overall risk of leprosy, and the causal variants and genes within these loci remain unknown. Here, we performed a meta-analysis of GWASs for leprosy in two newly generated (5,007 cases and 4,579 controls) and multiple previously published (2,277 cases and 3,159 controls) datasets. Four novel and 14 previously reported risk loci were identified from these datasets. |
| Sample scope |
Monoisolate |
| Release date |
2023-01-31 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Genome‐wide meta‐analysis and fine‐mapping prioritize potential causal variants and genes related to leprosy
|
MedComm
|
10.1002/mco2.415
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
82230107
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81972946
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82173430
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82273545
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82103746
|
|
| the Academic promotion programme of Shandong First Medical University
|
|
2019LJ002
|
|
| the Key research and development program of Shandong Province
|
|
2021LCZX07
|
|
|
|
| Submitter |
Hong
Liu (hongyue2519@hotmail.com)
|
| Organization |
Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Veneorology, Shandong First Medical University & Shandong Academy of Medical Sciences |
| Submission date |
2023-01-31 |
