| Accession |
PRJCA014889 |
| Title |
Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus |
| Relevance |
Medical |
| Data types |
proteome
|
| Organisms |
Homo sapiens
|
| Description |
This was a longitudinal case-control study. CSF in 37 iNPH patients and 16 age-balanced controls was collected from September 2020 to March 2022, and analyzed using a mass spectrometry-based proteomics workflow. Clinical evaluation was performed on all iNPH patients, and 32 patients underwent ventriculoperitoneal shunting. Postoperative CSF was also collected from 10 iNPH patients who underwent shunting surgery. Bioinformatics analysis and the random forest model were performed to identify CSF proteome changes and predictors of clinical outcome. |
| Sample scope |
human cerebrospinal fluids |
| Release date |
2023-06-01 |
| Data provider |
|
| Biomaterial provider |
Second Affiliated Hospital of Zhejiang Univeristy |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Junming
Zhu (dr.zhujunming@zju.edu.cn)
|
| Organization |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission date |
2023-02-11 |
