| Accession |
PRJCA015171 |
| Title |
OH2 oncolytic viral has a powerful antitumor effect in glioblastoma |
| Relevance |
Medical |
| Data types |
Exome
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
We performed RNA-seq on samples (U87_count and Case1_count) before and after OH2 treatment to analyze the molecular mechanism of OH2-induced tumor regression. Primary cells from 3 OH2 treatment-sensitive patients (Case2; Case10; Case11) and 3 insensitive patients (Case3; Case9; Case12) for RNA-seq. Whole exome sequencing was performed on 8 patients to infer differences in genomic alterations between OH2-sensitive and OH2-insensitive patients. |
| Sample scope |
Monoisolate |
| Release date |
2024-02-29 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38537773
|
OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responses
|
Cancer Letters
|
10.1016/j.canlet.2024.216834
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Beijing Tiantan Hospital
|
|
N/A
|
Horizontal scientific research in Beijing Tiantan Hospital
|
|
|
| Submitter |
Wenbin
Li (liwenbin@ccmu.edu.cn)
|
| Organization |
Beijing Tiantan Hospital, Capital Medical University |
| Submission date |
2023-02-23 |
