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Accession PRJCA015245
Title Single-cell sequencing reveals the developmental program of proximal-distal patterning of human lung at embryonic stage
Relevance Development
Data types Transcriptome or Gene expression
Single cell sequencing
Organisms Homo sapiens
Description The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange. However, the regulation of proximal-distal patterning at the embryonic stage of the human lung has not been explored. Here we investigated the early lung development of human embryos weeks 4-8 post-fertilization (Carnegie stages 12 to 21) using single-cell sequencing.We observed discernible gene expression patterns of proximal and distal epithelia at week 4, upon the initiation of lung organogenesis. Moreover, we newly identified transcriptional regulators of the patterning proximal and distal epithelia.
Sample scope Single cell
Release date 2024-03-09
Publication
PubMed ID Article title Journal name DOI Year
37085732 Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage Cell Research 10.1038/s41422-023-00802-6 2023
39003323 Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity Nature Communications 10.1038/s41467-024-50281-5 2024
Grants
Agency program Grant ID Grant title
National Key Research and Development Program of China 2020YFA0112400
National Key Research and Development Program of China 2019YFA0110200
The National Natural Science Foundation of China 32225012
The National Natural Science Foundation of China 92068201
The National Natural Science Foundation of China 21907095
The National Natural Science Foundation of China 82072880
The National Natural Science Foundation of China 32200662
The Pearl River Talent Recruitment Program 2021ZT09Y233
Major Science and Technology Program of Hainan Province ZDKJ2021037
Major Science and Technology Program of Hainan Province ZDKJ2017007
Hainan Provincial Science and Technology Program for Clinical Medical Research Center LCYX202102
Hainan Provincial Science and Technology Program for Clinical Medical Research Center LCYX202203
Hainan Provincial Science and Technology Program for Clinical Medical Research Center LCYX202301
Frontier Science Research Program of the Chinese Academy of Sciences ZDBS-LY-SM007
Science and Technology Planning Project of Guangdong Province, China 2020B1212060052
Submitter Jiekai Chen (chen_jiekai@gibh.ac.cn)
Organization Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Submission date 2023-02-27

Project Data

Resource name Description