| Accession |
PRJCA015294 |
| Title |
The impact of microplastics on the hematopoietic system |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
metabolome
|
| Organisms |
Mus musculus
Bacteria
human gut metagenome
|
| Description |
As microplastics mainly presented in the gastrointestinal system, we first performed the 16S rRNA and metabolomic analysis of feces from mice treated with or without microplastics. Next, we conducted the RNA-seq analysis of LT-HSCs to investigate the underlying mechanisms. Finally, the16S rRNA data of feces from the donors of patients who underwent hematopoietic cell transplantation were used for validation. |
| Sample scope |
Multispecies |
| Release date |
2024-04-23 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38548771
|
Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis
|
Cell Discovery
|
10.1038/s41421-024-00665-0
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
82222003
|
|
|
|
| Submitter |
Pengxu
Qian (axu@zju.edu.cn)
|
| Organization |
Zhejiang University School of Medicine |
| Submission date |
2023-02-21 |
