项目编号 PRJCA015294
项目标题 The impact of microplastics on the hematopoietic system
涉及领域 Medical
数据类型 Transcriptome or Gene expression
metabolome
物种名称 Mus musculus
Bacteria
human gut metagenome
描述信息 As microplastics mainly presented in the gastrointestinal system, we first performed the 16S rRNA and metabolomic analysis of feces from mice treated with or without microplastics. Next, we conducted the RNA-seq analysis of LT-HSCs to investigate the underlying mechanisms. Finally, the16S rRNA data of feces from the donors of patients who underwent hematopoietic cell transplantation were used for validation.
样品范围 Multispecies
发布日期 2024-04-23
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
38548771 Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis Cell Discovery 10.1038/s41421-024-00665-0 2024
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund 82222003
提交者 Pengxu Qian (axu@zju.edu.cn)
提交单位 Zhejiang University School of Medicine
提交日期 2023-02-21

项目包含数据信息

资源名称 描述
BioSample (52)  show -
GSA (3) -
CRA010086 The RNA-seq data of LT-HSCs in mice
CRA010068 The 16S rRNA data of gut microbiota from human
CRA010069 The 16S rRNA data of gut microbiota from mice