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Accession PRJCA015318
Title Molecular mechanism of highly pathogenic virus infection and pathogenicity
Relevance Medical
Data types Assembly
Organisms Echovirus
Severe acute respiratory syndrome coronavirus 2
Human alphaherpesvirus 2
Argentinian mammarenavirus
Hepatovirus A
Human alphaherpesvirus 1
Avian orthoavulavirus 1
Echovirus E30
African swine fever virus
Norovirus Hu/GII.P7/AM120027/2012/AM/BRA
Enterovirus B
Description For highly pathogenic viruses such as small RNA virus, herpes virus, yellow virus, etc., we plan to develop the construction of technical system for high-resolution structural research of virus particles by using freeze electron microscopy technology. By studying the three-dimensional structure and inhibition mechanism of virus particles, virus particles and receptors, antibodies, and invasion inhibitor complexes, propose theoretical methods for optimizing and improving the recombinant vaccine to form a rapid response to severe infectious diseases. The situation of effective response is the main implementation content and ultimate goal of this project.
Sample scope recombinant proteins
Release date 2023-03-02
Publication
PubMed ID Article title Journal name DOI Year
29622627 Cryo-EM structure of a herpesvirus capsid at 3.1 A Science 10.1126/science.aao7283 2018
30201968 Structure of the herpes simplex virus type 2 C capsid with capsid-vertex-specific component Nature Communications 10.1038/s41467-018-06078-4 2018
30478256 Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating Nature Communications 10.1038/s41467-018-07531-0 2018
30333166 Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths Journal of Virology 10.1128/JVI.01655-18 2018
31711377 Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses Emerging Microbes & Infections 10.1080/22221751.2019.1686335 2019
31039149 Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors plos biology 10.1371/journal.pbio.3000229 2019
31624094 Architecture of African swine fever virus and implications for viral assembly Science 10.1126/science.aaz1439 2019
32887891 Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage nature communications 10.1038/s41467-020-18251-9 2020
32887892 Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B nature communications 10.1038/s41467-020-18250-w 2020
32328903 Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation Protein Cell 10.1007/s13238-020-00710-0 2020
32285350 Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation Protein Cell 10.1007/s13238-020-00711-z 2020
34676096 Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2 National Science Review 10.1093/nsr/nwaa297 2020
34035235 Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody Cell Discovery 10.1038/s41421-021-00264-3 2021
34226547 Structural basis for recognition and regulation of arenavirus polymerase L by Z protein nature communications 10.1038/s41467-021-24458-1 2021
35658530 Structural Insight into Terminal Galactose Recognition by Two Non-HBGA Binding GI.3 Noroviruses Journal of virology 10.1128/jvi.00420-22 2022
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2017YFC0840301 Molecular mechanism of highly pathogenic virus infection and pathogenicity
External link
External link Link description
https://www.rcsb.org/ PDB database
Submitter Yutao Chen (chenyutao@ibp.ac.cn)
Organization Institute of Biophysics, Chinese Academy of Sciences
Submission date 2023-03-02

Project Data

Resource name Description