| 项目编号 |
PRJCA015354 |
| 项目标题 |
Human specific enhancer enh9 implements its pleiotrophic function in non-small cell lung cancer via ERMP1 and PD-L1 |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
We reported that enh9 stimulates both cell proliferation and migration intrinsically in non-small cell lung cancer (NSCLC) cells. As independent downstream targets of enh9, endoplasmic reticulum metallopeptidase 1 (ERMP1) and programmed death ligand 1 (PD-L1) are involved in cell proliferation and migration, respectively. CUT&Tag sequencing confirmed the transcription factor RELA mediated the interaction between enh9 and the promoters of ERMP1 and PD-L1. The manipulation of enh9 is a potential therapeutic strategy by blocking multiple oncogenic processes in cancer cells. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2023-03-13 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38182069
|
The pleiotropic enhancer enh9 promotes cell proliferation and migration in non-small cell lung cancer via ERMP1 and PD-L1
|
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
|
10.1016/j.bbadis.2023.167015
|
2024
|
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| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
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| 提交者 |
chunyan
li (lichunyan_buaa@163.com)
|
| 提交单位 |
Beihang University |
| 提交日期 |
2023-03-04 |
