| Accession |
PRJCA015535 |
| Title |
Spermine Is a Natural Suppressor of AR Signaling in Castration-Resistant Prostate Cancer |
| Relevance |
Medical |
| Data types |
Epigenomics
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
We demonstrate spermine as an anti-cancer metabolite by inhibiting PRMT1 to transcriptionally inhibit AR-FL and AR-V7 signaling in CRPC, and indicate spermine and PRMT1 inhibition as powerful strategies overcoming limitations of current AR-based therapies in CRPC |
| Sample scope |
Monoisolate |
| Release date |
2023-06-06 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37453063
|
Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
|
Cell Reports
|
10.1016/j.celrep.2023.112798
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
32125013
|
|
| National Natural Science Foundation of China (NSFC)
|
|
91853205
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81821005
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81803554
|
|
| Chinese Academy of Sciences (CAS)
|
|
XDA16020905
|
|
|
|
| Submitter |
dong
gao (dong.gao@sibcb.ac.cn)
|
| Organization |
Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences |
| Submission date |
2023-03-14 |
