| 描述信息 |
Human endometrial receptivity determines the success of pregnancy; however, in vivo studies of its features and regulation are particularly challenging due to ethical restriction. Recently, developed human endometrial organoids present a powerful model to dissect this complexity. Although there have been many major advances in the field of reproduction, human maternal-fetal interaction during the implantation window remains ambiguous, which is limited by research ethics. Recent developed endometrial organoids have been widely used as a powerful tool to explore the physiological and pathological features of human endometrium in vitro. Here, we successfully develop a receptive endometrial organoid, which reflect the features of human receptive endometrium during implantation window. Combined with the high-resolution omics including single cell sequencing, transcriptome, proteome and secretome, we demonstrated that the organoids we established showed similar cellular composition, function and transcriptional regulation as in vivo receptive endometrium. |
