| Accession |
PRJCA015636 |
| Title |
Chromatin accessibility complex subunit 1 is required for oncogenic transcription and tumor growth in multiple cancers |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
CHRAC1, a member of the chromatin remodeling family, plays a crucial role in DNA transcription and replication, and is also involved in the regulation of cell cycle. However, its role in tumorigenesis is rarely studied. In the current study, we validated that CHRAC1 promoted the proliferation of breast and cervical cancer cells by enhancing the transcription of YAP target oncogenes. Moreover, we observed increased expression of CHRAC1 in various tumor tissues, and high expression of CHRAC1 was associated with YAP and poor prognosis in cancer patients. These results suggest that CHRAC1 plays an important role in cancer development and may be a potential target for cancer therapy. |
| Sample scope |
Monoisolate |
| Release date |
2023-08-11 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82273064
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81902853
|
|
|
|
| Submitter |
Huixia
Zhang (hxzhang@hust.edu.cn)
|
| Organization |
Huazhong University of Science and Technology |
| Submission date |
2023-03-19 |
