| Accession |
PRJCA015706 |
| Title |
Adhesion GPCR ADGRE2 promotes acute myeloid leukemia progression by activating the AP-1/DUSP1/DNAJB1 axis and regulating proteostasis |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
We systematically analyzed the expression and clinical outcome of more than 800 GPCRs in AML. We identified an GPCR ADGRE2 as an oncogene in AML. Silencing of ADGRE2 impaired the functions of AML in vitro and in vivo. Mechanistically, ADGRE2 activated PLC-β/PKC/MEK/ERK signaling to enhance expression of AP-1 and DUSP1. DUSP1 decreased the serine phosphorylation of chaperone DNAJB1, which facilitated interaction of DNAJB1 and HSP70 and maintained proteostasis in AML. Combined inhibition of MEK, AP-1 and DUSP1 exhibited remarkable therapeutic efficacy for AML in xenograft model. |
| Sample scope |
Monoisolate |
| Release date |
2024-03-12 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Adhesion GPCR ADGRE2 Maintains Proteostasis to Promote Progression in Acute Myeloid Leukemia
|
Cancer Research
|
10.1158/0008-5472.CAN-23-2314
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82222003
|
|
|
|
| Submitter |
Pengxu
Qian (axu@zju.edu.cn)
|
| Organization |
Zhejiang University School of Medicine |
| Submission date |
2023-03-15 |
