| Description |
Viral infections cause a variety of human diseases and pose a serious threat to human health. The innate immunity is the first line of host defense against foreign microorganisms, which has a wide range of action and rapid response, so it can quickly establish immune response and inhibit virus replication in the early process of virus infection. Meanwhile, in order to escape the innate immune response of the host, the virus has evolved a series of strategies to help the virus effectively infect the host and replicate. With the support of this project, we will focuses on two important types of viruses, herpesvirus and coronavirus, and takes "innate immune signaling in the process of viral infection" as the breakthrough, focuses on the key scientific issue of "the interaction between viral infection and natural immune system", starts from the aspects of "virus replication and escape of innate immune response" and "host innate immune inhibits viral replication", and comprehensively uses virology, cell biology, immunology, structural biology and other research methods to carry out the research. |
