| 项目编号 |
PRJCA015864 |
| 项目标题 |
structural and functional studies of variant nucleosome and nucleosome modifications |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
|
| 物种名称 |
Human gammaherpesvirus 4
Homo sapiens
Saccharomyces
|
| 描述信息 |
This project will study the structure of H2A variant nucleosome which is significantly different from the conventional nucleosome structure, as well as the complex structure formed by chromatin modifying enzymes, chromatin remodeling complex subunits and nucleosome, comprehensively using structural biology and biochemistry methods such as cryo-electron microscopy, X-ray crystallography, monomolecular magnetic forceps. Our study aims to reveal the structural basis and molecular mechanism of variant nucleosome and nucleosome modification regulating chromatin dynamics, clarify their important roles in DNA replication, transcription, repair and other life activities, and explore potential drug targets with promising application prospects. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-12-31 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDB37000000
|
structural and functional studies of variant nucleosome and nucleosome modifications
|
|
|
| 提交者 |
Xiaoli
Feng (fengxiaoli81@ibp.ac.cn)
|
| 提交单位 |
Institute of Biophysics, Chinese Academy of Sciences |
| 提交日期 |
2023-03-27 |
