| Accession |
PRJCA015890 |
| Title |
Molecular mechanism of amino acids induced mTORC1 signaling pathway in eukaryotes. |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Chlamydomonas reinhardtii
Homo sapiens
Drosophila melanogaster
|
| Description |
In eukaryotic cells, mTORC1 is a highly conserved protein kinase complex that regulates cell growth and development, autophagy, protein synthesis and degradation, and other important biological processes. Dysfunction of the mTORC1 signaling pathway can cause a variety of diseases including tumors. Amino acids are important activators of mTORC1, but the molecular mechanisms of how amino acid signals are perceived and transmitted to mTORC1 and how mTORC1 is activated and inhibited are not clear. Recent studies have found that amino acid-induced activation of mTORC1 signaling pathway is mainly carried out on lysosomes, and a series of protein complexes are involved in the regulation of this complex process but the function of these complexes and the molecular mechanisms by which they function are unclear. This project will use structural biology, biochemistry, molecular biology and cell biology methods to search for and identify new amino acid sensors and interacting proteins, and reveal their functions, regulatory networks and structural basis in the amino acid-induced mTORC1 signaling pathway regulation. |
| Sample scope |
Monoisolate |
| Release date |
2023-04-12 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex
|
structure
|
10.1016/j.str.2021.10.013
|
2021
|
|
|
Molecular mechanism for vitamin C-derived C5-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1
|
Nature communications
|
10.1038/s41467-021-21061-2
|
2021
|
|
|
HBO1 is a versatile histone acyltransferase critical for promoter histone acylations
|
Nucleic acids research
|
doi.org/10.1093/nar/gkab607
|
2021
|
|
|
Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations
|
Cell Discovery
|
doi.org/10.1038/s41421-020-00227-0
|
2021
|
|
|
Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
|
Science Advances
|
10.1126/sciadv.abn3868
|
2022
|
|
|
Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling
|
Journal of Molecular Cell Biology
|
doi.org/10.1093/jmcb/mjaa025
|
2020
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
|
XDB37000000
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2020YFA0509000
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2020YFA0803200
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31530013
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31870723
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31800622
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31870722
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32071190
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31801060
|
|
|
|
| Submitter |
Yifan
Zhang (zhangyifan2017@sibcb.ac.cn)
|
| Organization |
Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences |
| Submission date |
2023-03-27 |
