| 项目编号 |
PRJCA015898 |
| 项目标题 |
Construction of a risk stratification model integrating ctDNA dynamic monitoring to predict response and survival in neoadjuvant-treated breast cancer |
| 涉及领域 |
Medical |
| 数据类型 |
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
In our study, a total of 269 breast cancer patients received NAC from 2 hospitals were prospectively enrolled. Among them, the tissue samples were sequenced using a panel covering 457 cancer-related genes, and 216 blood samples at the indicated time points were collected for ctDNA detection from 56 patients. We established a predictive model for predicting pCR after NAC. At the same time, ctDNA dynamic monitoring found that ctDNA status can predict NAC response and metastasis recurrence. Combining the prediction model and ctDNA status can better predict the NAC results and predict the prognosis for distinguish high- and low-risk patients, which may be helpful to guide subsequent treatment strategies in breast cancer after surgery. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-03-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38087296
|
Construction of a risk stratification model integrating ctDNA to predict response and survival in neoadjuvant-treated breast cancer
|
BMC Medicine
|
10.1186/s12916-023-03163-4
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81972863
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81627901
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82030082
|
|
| the Academic Promotion Program of Shandong First Medical University
|
|
2019ZL002
|
|
| Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences
|
|
2019RU071
|
|
|
|
| 提交者 |
Jinming
Yu (sdyujinming@163.com)
|
| 提交单位 |
Shandong First Medical University and Shandong Academy of Medical Sciences |
| 提交日期 |
2023-03-28 |
