| Accession |
PRJCA015936 |
| Title |
Spatial Multiomics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC |
| Relevance |
Medical |
| Data types |
Raw mass spectrometry data
|
| Organisms |
Homo sapiens
|
| Description |
Oral submucous fibrosis (OSF) is one of the most common precancerous malignant lesions (PML) with high rates exacerbating into oral squamous cell carcinoma (OSCC), mostly occurred in patients with chewing betel-nut habits in Southeast Asia and Pacific region. However, the spatial characteristics and heteogeneities of tumor microenvironment (TME) in OSF-associated OSCC still remains unclear. Here. we characterized the spatiotemporal changes of OSF-associated OSCC at different malignant states by performing 10x Visium Spatial Transcriptomics (ST) sequencing and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) analysis. |
| Sample scope |
Multiisolate |
| Release date |
2024-02-02 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38229179
|
Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis-Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment
|
Advanced Science
|
10.1002/advs.202306515
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Wei
Xiong (xiongwei@csu.edu.cn)
|
| Organization |
Central South University |
| Submission date |
2023-03-30 |
