| 项目编号 |
PRJCA015936 |
| 项目标题 |
Spatial Multiomics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC |
| 涉及领域 |
Medical |
| 数据类型 |
Raw mass spectrometry data
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Oral submucous fibrosis (OSF) is one of the most common precancerous malignant lesions (PML) with high rates exacerbating into oral squamous cell carcinoma (OSCC), mostly occurred in patients with chewing betel-nut habits in Southeast Asia and Pacific region. However, the spatial characteristics and heteogeneities of tumor microenvironment (TME) in OSF-associated OSCC still remains unclear. Here. we characterized the spatiotemporal changes of OSF-associated OSCC at different malignant states by performing 10x Visium Spatial Transcriptomics (ST) sequencing and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) analysis. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-02-02 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38229179
|
Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis-Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment
|
Advanced Science
|
10.1002/advs.202306515
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| 提交者 |
Wei
Xiong (xiongwei@csu.edu.cn)
|
| 提交单位 |
Central South University |
| 提交日期 |
2023-03-30 |
