项目编号

PRJCA015989

项目标题

Systematic screening of functional maternal-specific chromatin regulators in early embryonic development

涉及领域

Model organism

数据类型

Whole genome sequencing
Transcriptome or Gene expression
Raw sequence reads

物种名称

Danio rerio

描述信息

The early stages of embryonic development rely on maternal products for proper regulation. However, systematic screening for functional maternal-specific factors has been challenging due to the time- and labor-intensive nature of traditional approaches. Here, we combined a computational pipeline and F0 homozygous mutation technology to screen for functional maternal-specific chromatin regulators in zebrafish embryogenesis and identified Mcm3l, Mcm6l, and Npm2a that play essential roles in DNA replication and cell division. Our results contribute to understanding the molecular mechanisms underlying early embryo development and highlight the importance of maternal-specific chromatin regulators in this critical stage.

样品范围

Multiisolate

发布日期

2024-09-23

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
39427068	Screening of functional maternal-specific chromatin regulators in early embryonic development of zebrafish	Communications Biology	10.1038/s42003-024-06983-z	2024

项目资金来源

机构	项目类型	授权项目ID
National Natural Science Foundation of China (NSFC)	Key Program	32030022
National Natural Science Foundation of China (NSFC)	General Program	31970642
Ministry of Science and Technology of the People's Republic of China (MOST)	National Key Technologies R&D Program	2021YFA1302500

提交者

Yong Zhang (yzhang@tongji.edu.cn)

提交单位

Tongji University

提交日期

2023-04-01

项目包含数据信息

资源名称	描述
BioSample (20) show	-
SAMC1187492	Mnpm2a 5.5 hpf embryo more than 4N replicate 2
SAMC1187491	Mnpm2a 5.5 hpf embryo more than 4N replicate 1
SAMC1187490	Mnpm2a 4.5 hpf embryo more than 4N replicate 2
SAMC1187489	Mnpm2a 4.5 hpf embryo more than 4N replicate 1
SAMC1187488	Mnpm2a 3 hpf embryo more than 4N replicate 2
SAMC1187487	Mnpm2a 3 hpf embryo more than 4N replicate 1
SAMC1187486	Mnpm2a 2.5 hpf embryo more than 4N replicate 2
SAMC1187485	Mnpm2a 2.5 hpf embryo more than 4N replicate 1
SAMC1187484	Mnpm2a 5.5 hpf embryo less than 2N replicate 2
SAMC1187483	Mnpm2a 5.5 hpf embryo less than 2N replicate 1
SAMC1187482	Mnpm2a 4.5 hpf embryo less than 2N replicate 2
SAMC1187481	Mnpm2a 4.5 hpf embryo less than 2N replicate 1
SAMC1187480	Mnpm2a 3 hpf embryo less than 2N replicate 2
SAMC1187479	Mnpm2a 3 hpf embryo less than 2N replicate 1
SAMC1187478	Mnpm2a 2.5 hpf embryo less than 2N replicate 2
SAMC1187477	Mnpm2a 2.5 hpf embryo less than 2N replicate 1
SAMC1187476	Mnpm2a 3.66 hpf embryo replicate 2
SAMC1187475	Mnpm2a 3.66 hpf embryo replicate 1
SAMC1187474	WT 3.66 hpf embryo replicate 2
SAMC1187473	WT 3.66 hpf embryo replicate 1
GSA (1)	-
CRA010494	Screening of functional maternal-specific chromatin regulators in early embryonic development of zebrafish