| Accession |
PRJCA015999 |
| Title |
Metabolome of Epinephrine-treated or untreated M.tb H37Ra |
| Relevance |
Medical |
| Data types |
Metabolome
|
| Organisms |
Mycobacterium tuberculosis H37Ra
|
| Description |
Human stress hormones have been studied as a source of communication among human micro biota and their hosts. Therefore, we hypothesized thatHowever, whether M. tuberculosis would also sense and response to certain types of human stress hormones remain elusive. Here we screened human catecholamin stress hormones against M. tuberculosis and checked their effects on the bacteria. Our results showed that epinephrine significantly stimulated the growth of M. tuberculosis in serum-based medium as well as macrophages. In silico analysis and molecular docking results suggested that the senser part of the mprB might be the putative adrenergic sensor. Further study showed that epinephrine significantly enhances M. tuberculosis biofilm formation, which with distinct textures and compositions and is resistant to antibiotics. Together these results demonstrated that epinephrine stimulates the growth and biofilm formation of M. tuberculosis. |
| Sample scope |
Monoisolate |
| Release date |
2024-01-04 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38139199
|
Epinephrine Stimulates Mycobacterium tuberculosis Growth and Biofilm Formation
|
International Journal of Molecular Sciences
|
10.3390/ijms242417370
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
31602061
|
|
|
|
| Submitter |
Xiaojian
Cao (Stargazer@webmail.hzau.edu.cn)
|
| Organization |
Huazhong Agricultural University |
| Submission date |
2023-04-01 |
