| Accession |
PRJCA016054 |
| Title |
SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α |
| Relevance |
Medical |
| Data types |
IP-MS
|
| Organisms |
Homo sapiens
|
| Description |
From the perspective of virus-host interaction, this project proposed the scientific hypothesis that "HBV infection induces ubiquitination modification of SPOP, which inhibits HBV cccDNA transcription and regulates HBV replication by degrading intrahepatic transcription factors through ubiquitination", which can be used as a potential target for anti-HBV. |
| Sample scope |
Monoisolate |
| Release date |
2023-12-29 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α
|
Journal of Medical Virology
|
10.1002/jmv.29254
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82102377
|
|
|
|
| Submitter |
yubo
pi (2021110788@stu.cqmu.edu.cn)
|
| Organization |
Chongqing Medical University |
| Submission date |
2023-04-04 |
