| 项目编号 |
PRJCA016095 |
| 项目标题 |
Methylomic signatures of high-altitude acclimatization and adaptation in Tibetan Plateau. |
| 涉及领域 |
Environmental |
| 数据类型 |
Epigenomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
High altitude presents a challenging environment for human settlement. DNA methylation is an essential epigenetic mechanism that responds to environmental stimuli, but its roles in high-altitude short-term acclimatization (STA) and long-term adaptation (LTA) are poorly understood. Here, we conducted a methylome-wide association study involving 840 native highlanders and 310 acclimatized newcomers in the Tibetan Plateau and 472 native lowlanders to identify differentially methylated sites (DMSs) associated with STA or LTA. |
| 样品范围 |
human whole blood |
| 发布日期 |
2023-12-31 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40328746
|
Distinct methylomic signatures of high-altitude acclimatization and adaptation in the Tibetan Plateau
|
Cell Discovery
|
10.1038/s41421-025-00795-z
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang
|
|
2021R01013
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81522014
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82125007
|
|
|
|
| 提交者 |
Jian
Yang (jian.yang@westlake.edu.cn)
|
| 提交单位 |
Westlake University |
| 提交日期 |
2023-03-28 |
