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Accession PRJCA016272
Title Tumor microenvironmental determinants of immunotherapy response in esophageal squamous cell carcinoma
Relevance Medical
Data types Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
Organisms Homo sapiens
Description Immune checkpoint blockade(ICB) leads promising results in esophageal squamous cell carcinoma(ESCC) patients. However, the tumor microenvironment changes underlying ICB response in Esophageal Squamous Cell Carcinoma(ESCC) are unclear. Here we performed single-cell RNA sequencing and T/B cell receptor sequencing(scRNA-Seq/scTCR-Seq/scBCR-Seq) of the 27 ESCC patients before or after ICB treatment.
Sample scope Single cell
Release date 2025-04-15
Data provider
Data provider Data provider URL
Department of Thoracic Surgery, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer https://www.zchospital.com/en/index
Biomaterial provider Department of Thoracic Surgery, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 82172567
Zhejiang Provincial Natural Science-Mathematical Medicine Association Joint Fund LSY19H160001
Zhejiang Traditional Chinese Medicine Excellent Young Talents Fund Project 2021ZQ015
Westlake Education Foundation, Westlake Laboratory of Life Sciences and Biomedicine N/A
Submitter Xi Wang (wangxi@westlake.edu.cn)
Organization WESTLAKE UNIVERSITY
Submission date 2023-04-13

Project Data

Resource name Description
BioSample (27)  show -