| 项目编号 |
PRJCA016396 |
| 项目标题 |
RIG-I is an intracellular checkpoint that limits CD8+ T-cell antitumor immunity |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
RIG-I is a pattern recognition receptor involved in innate immunity, but its role in adaptive immunity remains unclear. Here, we demonstrate that RIG-I is upregulated in tumor infiltrating CD8+ T cells, where it functions as an intracellular checkpoint to negatively regulate CD8+ T cell function and limit antitumor immunity. Mechanically, up-regulation of RIG-I in CD8+ T cells is induced by retinoic acid (RA), a metabolite of vitamin A in TME, and direct inhibits the AKT/glycolysis signaling pathway. In addition, deletion of RIG-I enhances the efficacy of adoptively transferred T cells against solid tumors and inhibition of RIG-I enhances the response to PD-1 blockade. Our findings identify RIG-I as an intracellular checkpoint and a potential target for alleviating inhibitory constraints on T cells in cancer immunotherapy, either alone or in combination with immune checkpoint blockade. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-04-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39322862
|
RIG-I is an intracellular checkpoint that limits CD8 + T-cell antitumour immunity
|
EMBO Molecular Medicine
|
10.1038/s44321-024-00136-9
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82103433
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82204415
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32200936
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2020A1515110013
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2021A1515220187
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2021A1515110561
|
|
| Shenzhen Science and Technology Innovation Commission projects
|
|
JCYJ20220818101808018
|
|
|
|
| 提交者 |
ligong
lu (luligong1969@jnu.edu.cn)
|
| 提交单位 |
Zhuhai People's Hospital Affiliated with Jinan University |
| 提交日期 |
2023-04-19 |
