| 项目编号 |
PRJCA016721 |
| 项目标题 |
Neoadjuvant Camrelizumab plus Chemotherapy for Locally Advanced Cervical Cancer |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
we initiated a phase 2 NACIT study to explore the efficacy and safety of NACT combined with PD-1 inhibitors followed by radical hysterectomy in PD-L1 positive LACC. Our findings demonstrate promising antitumor activity, high feasibility, and durable toxicity with neoadjuvant immunochemotherapy. Additionally, our multi-omics tests, including whole-exome sequencing (WES), longitudinal transcriptome sequencing, and multicolor immunohistochemistry, reveal that pre-treatment immune cell infiltration is a biomarker for pathological complete responses. Furthermore, the longitudinal transcriptome analysis revealed dynamic changes in the immune microenvironment, providing valuable insights into the biology of neoadjuvant immunochemotherapy in cervical cancer. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-07-20 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82101700
|
|
|
|
| 提交者 |
Kezhen
Li (tjkeke@126.com)
|
| 提交单位 |
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| 提交日期 |
2023-05-04 |
