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项目编号 PRJCA016745
项目标题 Single-cell profiling revealed tumor heterogeneity and microenvironment in surgically resectable esophageal squamous cell carcinoma with neoadjuvant chemoimmunotherapy
涉及领域 Medical
数据类型 Single cell sequencing
物种名称 Homo sapiens
描述信息 This study enrolled 22 patients diagnosed with stage II to IV ESCC, of whom 20 underwent neoadjuvant tislelizumab combined with chemotherapy before surgical removal and two were treated with camrelizumab plus chemotherapy before surgery. The dataset performed single-cell transcriptomic data of a total of 259,003 cells derived from 22 baseline and 24 post-NAT treatment samples of 22 stage II/III resectable ESCC patients.
样品范围 Multiisolate
发布日期 2023-06-16
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
38566201 Single-cell profiling of response to neoadjuvant chemo-immunotherapy in surgically resectable esophageal squamous cell carcinoma Genome Medicine 10.1186/s13073-024-01320-9 2024
39334513 Functional heterogeneity of cancer-associated fibroblasts with distinct neoadjuvant immunotherapy plus chemotherapy response in esophageal squamous cell carcinoma Biomarker Research 10.1186/s40364-024-00656-z 2024
Constructing a Predictive Model for PD-1 Blockade Therapy in Pan-Cancer Based on Machine Learning Research Square 10.21203/rs.3.rs-6317412/v1 2025
AKB-9778-induced tumor vascular normalization enhances the efficacy of immunotherapy in oral cancer International Immunopharmacology 10.1016/j.intimp.2025.114133 2025
40406147 Single-cell RNA sequencing reveals adrb1 as a sympathetic nerve-regulated immune checkpoint driving T cell exhaustion and impacting immunotherapy in esophageal squamous cell carcinoma Frontiers in Immunology 10.3389/fimmu.2025.1520766 2025
41099937 Integrated single-cell and Mendelian randomization analyses: dissecting underlying causes of varied efficacy in immune neoadjuvant therapy for esophageal carcinoma Discover Oncology 10.1007/s12672-025-03751-1 2025
41373733 Construction of Metastasis Prediction Models and Screening of Anti-Metastatic Drugs Based on Pan-Cancer Single-Cell EMT Features International Journal of Molecular Sciences 10.3390/ijms262311582 2025
41305010 Harnessing Single-Cell RNA-Seq for Computational Drug Repurposing in Cancer Immunotherapy Pharmaceuticals 10.3390/ph18111769 2025
41286177 Discovery and validation of proliferative exhausted T cells as a favorable prognostic biomarker in esophageal squamous cell carcinoma Scientific Reports 10.1038/s41598-025-25535-x 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Tangdu Hospital,Air Force Military Medical University, Xi'an,710038, P. R. China N/A
提交者 Qiang Lu (luqiang@fmmu.edu.cn)
提交单位 Air Force Medical University
提交日期 2023-04-28

项目包含数据信息

资源名称 描述
BioSample (46)  show -