| 项目编号 |
PRJCA016768 |
| 项目标题 |
Spatially resolved multi-omics decipher cellular responses heterogeneity and metabolic reprogramming in aristolochic acid nephropathy |
| 涉及领域 |
Model organism |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Aristolochic acid nephropathy (AAN), mainly caused by overexposure to aristolochic acid I (AAI), is characterized by acute renal injury, interstitial nephritis, and metabolic dysfunction. Previously, we have demonstrated the effects of AAI on cellular-specific responses, microenvironment remodeling, and metabolic pathways. However, the lack of spatial information in these datasets hinders our understanding of the pathological mechanism of AAN. In this study, by integrating spatial transcriptomics with spatial metabolomics methods, we established a spatial multi-omics analysis that allows for in situ deciphering of region-specific responses and metabolic reprogramming in AAN,providing novel insights into deciphering AAN's cellular and molecular mechanism in the spatial context, pointing out potential intervention pathways to alleviate the global AAN burden. |
| 样品范围 |
spatial transcriptome |
| 发布日期 |
2024-12-22 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Spatially resolved multi-omics unravels region-specific responses, microenvironment remodeling and metabolic reprogramming in aristolochic acid nephropathy
|
The Innovation Medicine
|
10.59717/j.xinn-med.2024.100066
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82141001
|
|
|
|
| 提交者 |
yunmeng
bai (2856450699@qq.com)
|
| 提交单位 |
Shenzhen People's Hospital |
| 提交日期 |
2023-05-06 |
