| Accession |
PRJCA016884 |
| Title |
IL-10 Down-regulates CD44 Expression and Negatively Regulates BCG-induced Pulmonary Memory CD4+T Cells |
| Relevance |
Medical |
| Data types |
Map
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
Homo sapiens
|
| Description |
We previously reported that M.tb/BCG lipoglycan antigen induced host cells to produce IL-10. We found that CD44, the multifunctional cell surface adhesion molecule on CD4+ T cells, was downregulated in the presence of IL-10. These results suggest that IL-10 might inhibit CD44 expression and hinder the development of BCG-induced immune memory. In our current work, we plan to investigate the mechanisms of IL-10-regulated CD44 expression, CD44-mediated cytoskeletal rearrangement and cell migration, as well as the development of CD4+TEM/TRM in the lung during BCG immunization. Then we will block the IL-10 effect in vivo and assess the development of CD4+TEM/TRM in the lung during BCG immunization. Our work will provide new information of IL-10-regulated and CD44-medicated CD4+TEM/TRM formation in the lung, and contribute to developing the new strategy for improving the efficacy of the BCG-induced immune memory. |
| Sample scope |
Monoisolate |
| Release date |
2025-05-10 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81971908
|
IL-10 Down-regulates CD44 Expression and Negatively Regulates BCG-induced Pulmonary Memory CD4+T Cells
|
|
|
| Submitter |
Qin
Pan (panqincn@whu.edu.cn)
|
| Organization |
Wuhan University |
| Submission date |
2023-05-10 |
