| 项目编号 |
PRJCA016991 |
| 项目标题 |
Decoding the tumour immune microenvironment reveals the heterogeneity of dendritic cells and regulatory networks of T cells for bladder cancer immunotherapy |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Bladder cancer has high mortality and recurrence rates, and existing therapies are unsatisfactory. To develop new treatments, a comprehensive understanding of the tumour immune microenvironment is urgent. To explore the heterogeneity of dendritic cells and assess their relevance in bladder cancer treatment, we generated a high-resolution immune atlas based on paired malignant and non-malignant tissues from 11 bladder cancer patients. Patients with or without neoadjuvant chemotherapy were recruited in our cohort. Our large-scale atlas will deepen the understanding of the bladder cancer immune microenvironment. We highlight the role of DCs in bladder cancer immunotherapeutic potential. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-05-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40561775
|
High-resolution transcriptome atlas of bladder cancer highlights the functional myeloid subsets in modulating immune microenvironment
|
eBioMedicine
|
10.1016/j.ebiom.2025.105801
|
2025
|
|
|
| 实验材料提供者 |
Yajian Li |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2021YFA1301603
|
|
|
|
| 提交者 |
Yunping
Zhu (zhuyunping@ncpsb.org.cn)
|
| 提交单位 |
National center for Protein science (Beijing) |
| 提交日期 |
2023-05-15 |
