| 描述信息 |
Environment pollutants associated liver toxicity have captured increasing attention due to the increasing liver diseases in recent years. Endosulfan (ENDO), a widely used organochlorine insecticide, exerts potential health risks for multiple organs including liver. However, the underlying mechanisms of ENDO-induced liver injury remain largely unclear. Here, single cell RNA sequencing (scRNA-seq) was employed to investigate ENDO-induced liver toxicity in mice. Our results reveal that apart from inducing hepatocytes injury, ENDO activated hepatic stellate cells and lymphocytes, triggered significant inflammatory response. Moreover, myeloid cell recruitment and activation was also involved in ENDO-induced liver injury. Finally, the alteration of cell communications and liver microenvironment may also play a critical role in ENDO-associated liver injury. Overall, our results reveal key genes and cellular pathways for ENDO-induced liver toxicity at single-cell resolution, providing novel insight into understanding the liver injury associated with organochlorine insecticide such as endosulfan. |
