| Accession |
PRJCA017340 |
| Title |
Study on the structure of SARS-CoV-2 particles and their surface antigens, receptors, antibodies and vaccine complexes |
| Relevance |
Medical |
| Data types |
protein structures
|
| Organisms |
Severe acute respiratory syndrome coronavirus 2
|
| Description |
SARS-CoV-2 is a new infectious disease. Whether the epidemic can be scientifically handled and responded to in the future is an important challenge for China to face the threat of the virus, which also poses a severe challenge for our public health capacity. At present, it is urgent to speed up the research and development of SARS-CoV-2 vaccines and antiviral drugs. The whole virus structure of SARS-CoV-2 and the structural analysis of its neutralizing antibody and receptor complexes will provide a strong theoretical support for the prevention and treatment of the virus. At present, although several research groups have reported the three-dimensional structure of the recombinant SARS-CoV-2 surface glycoprotein Spike in vitro, the whole viral structure of SARS-CoV-2, including the surface antigen structure of the virus in its natural state, is still unknown, which has high practical significance and is extremely challenging. This project is intended to carry out structural research on the whole SARS-CoV-2 by combining virology, structural biology, immunology and other multi-disciplinary technologies. The whole virus particle structure of SARS-CoV-2 and the complex structure of whole virus particles with neutralizing antibodies and receptors to be analyzed in this topic will guide the vaccine development of SARS-CoV-2 and the screening of antiviral drugs more directly and accurately. |
| Sample scope |
recombinant proteins |
| Release date |
2023-05-29 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2020YFA0707503
|
Study on the structure of novel coronavirus particles and their surface antigens, receptors, antibodies and vaccine complexes
|
|
|
| Submitter |
Yutao
Chen (chenyutao@ibp.ac.cn)
|
| Organization |
Institute of Biophysics, Chinese Academy of Sciences |
| Submission date |
2023-05-29 |
