| Accession |
PRJCA017429 |
| Title |
Footprint-C: building high-resolution chromatin contact maps upon transcription factor footprints |
| Relevance |
Model organism |
| Data types |
3D genome
|
| Organisms |
Homo sapiens
Drosophila melanogaster
|
| Description |
Hi-C methods, the mainstream tools to study genome-wide chromatin interactions, often fragment the genome using enzymes functionally irrelevant to the interactions per se, restraining the efficiency in identifying structural features and the underlying regulatory elements. Here we present Footprint-C, which yields high-resolution chromatin contact maps built upon intact and genuine footprints protected by transcription factor (TF) binding. Footprint-C exhibits higher efficiency in identifying structural features when compared with other Hi-C methods, resolves interactions emanating from TF footprints, and reveals that a rich regulatory lexicon of complex TF-TF interactions underlies genome folding. |
| Sample scope |
Monoisolate |
| Release date |
2025-09-28 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| Submitter |
Chenhuan
Xu (xuchh@big.ac.cn)
|
| Organization |
Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation |
| Submission date |
2023-06-02 |
