| Description |
Esophagogastric junction adenocarcinomas (EGJA) are devastating diseases with increasing incidence. The Siewert classification is the well accepted anatomical classification system for EGJA to guide surgical approaches. However, the definition of EGJA and its optimal resection strategy are still debatable. 198 EGJA patients, of which 140 (70.7%) were distal EGJA, 58 (29.3%) were proximal EGJA, 42 gastric adenocarcinoma (GCA) patients and 36 esophageal squammous cell carcinomas (ESCC) patients were enrolled. Targeted next-generation sequencing (NGS) of 450 cancer-related genes was performed to identify the genomic alterations. The molecular characteristics of the above EGJA, GCA and ESCC were analyzed and compared. |
