| 项目编号 |
PRJCA017574 |
| 项目标题 |
METTL3-mediated LINC00475 alternative splicing promotes mitochondrial fission in glioblastoma |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project intends to use MeRIP, Pulldown-IP and other technologies in glioma cells and animal models to determine the binding sites of LINC00475 and HNRNPH1, to reveal the mechanism of METTL3-mediated LINC00475 splicing promoting mitochondrial fission by inhibiting MIF, and to clarify the clinical significance of the splicing variant 206 by analyzing the clinical samples and data. This project will reveal a new mechanism of mitochondrial fission in glioma and provide new ideas for glioma therapy. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2023-08-31 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38405130
|
METTL3-Mediated LINC00475 Alternative Splicing Promotes Glioma Progression by Inducing Mitochondrial Fission
|
Research
|
10.34133/research.0324
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81672496
|
Study on the mechanism of glioma mitochondria-specific high expression of miR-92b-5p regulating cell senescence
|
|
|
| 提交者 |
Xiao ping
Liu (liu_xiaoping@gwcmc.org)
|
| 提交单位 |
Guangzhou Women and Children's Medical Center |
| 提交日期 |
2023-06-08 |
