| Accession |
PRJCA017574 |
| Title |
METTL3-mediated LINC00475 alternative splicing promotes mitochondrial fission in glioblastoma |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
|
| Organisms |
Homo sapiens
|
| Description |
This project intends to use MeRIP, Pulldown-IP and other technologies in glioma cells and animal models to determine the binding sites of LINC00475 and HNRNPH1, to reveal the mechanism of METTL3-mediated LINC00475 splicing promoting mitochondrial fission by inhibiting MIF, and to clarify the clinical significance of the splicing variant 206 by analyzing the clinical samples and data. This project will reveal a new mechanism of mitochondrial fission in glioma and provide new ideas for glioma therapy. |
| Sample scope |
Monoisolate |
| Release date |
2023-08-31 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38405130
|
METTL3-Mediated LINC00475 Alternative Splicing Promotes Glioma Progression by Inducing Mitochondrial Fission
|
Research
|
10.34133/research.0324
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81672496
|
Study on the mechanism of glioma mitochondria-specific high expression of miR-92b-5p regulating cell senescence
|
|
|
| Submitter |
Xiao ping
Liu (liu_xiaoping@gwcmc.org)
|
| Organization |
Guangzhou Women and Children's Medical Center |
| Submission date |
2023-06-08 |
